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US attorney opens investigation into California elections-sends prosecutor to LA
New Treatment for Alzheimer's and Parkinson's Discovered in Japan
The intracies of modern camera lens repair (2024)
She won a religious exemption from using AI at work
The Shift in Peering Threatening the Internet's Foundations
Build Your Own "Longevity Scientist": A Paper-to-Action Agent using LangGraph & Mistral-7B
We live in an era where scientific breakthroughs are published faster than we can read them. For the biohacking community, the gap between a new PubMed study on NAD+ precursors and actually knowing what dose to take is a chasm of manual research. What if you could build an LLM Agent that monitors research papers, processes them through a RAG (Retrieval-Augmented Generation) pipeline, and maps findings to your specific health profile? In this tutorial, we are building Paper-to-Action , a state-of-the-art agentic workflow using LangGraph , ChromaDB , and Mistral-7B . This isn't just a simple bot; it's a multi-stage reasoning engine designed to turn raw academic data into actionable health interventions. If you've been looking to master AI agents and personalized medicine automation, you’re in the right place. 🚀 The Architecture: From Raw Paper to Personalized Habit Traditional RAG pipelines are linear. To handle the nuance of medical research, we need a "looping" logic. We use LangGraph to manage the state of our agent, allowing it to decide if a paper is relevant before attempting to extract a protocol. System Flow graph TD A[Start: Keyword Trigger] --> B[Search PubMed/Arxiv API] B --> C{Relevance Filter} C -- No --> B C -- Yes --> D[Store in ChromaDB] D --> E[RAG: Extract Intervention Protocol] E --> F[Cross-Reference with User Profile] F --> G[Generate Personalized Action Plan] G --> H[End: Push to Health Checklist] Prerequisites To follow this advanced guide, you'll need: LangGraph : For the agentic state machine. ChromaDB : As our high-performance vector store. Mistral-7B : Running via Ollama or vLLM for local, private inference. Python 3.10+ Step 1: Defining the Agent State In LangGraph, everything revolves around the State . We need to track the fetched papers, the extracted data, and the final recommendation. from typing import Annotated , List , TypedDict from langgraph.graph import StateGraph , END class AgentState ( TypedDict ): keywords : List [ str ] user
Nasdaq falls 4% and suffers worst day since April 2025 traders flee chip stocks
Omnipod 5 is coming to Loop and Trio this summer
Show HN: Courtside – TUI for NBA Games
Hi HN, I made this after seeing a few similar projects on the front page. NBA API endpoints are public and there’s a pretty robust python package ( https://github.com/swar/nba_api ) that I referenced for the endpoint structure to build an sdk in go. used BubbleTea and LipGloss for styling. It was a bit tricky to test the live endpoints but I watched Friday’s Final game with this and it worked pretty well playball - https://news.ycombinator.com/item?id=45451577 faceoff - https://news.ycombinator.
Nordstjernen 1.0
Show HN: Omni – Local-first multimodal file search on macOS
Finally made something I've always wanted, using the model we built. • SOTA omni embedding model, fully local, indexes text, PDF, image, audio, and video • Swift-native app UI + mlx-swift-transformer core. No Python. • Tested on M3 Pro 18G / M3 Ultra 512G / M4 Pro 48G. All work fine. • HTTP server exposes search to local agents like OpenClaw & Hermes − Indexing still feels slow even on the latest M3 Ultra, ranging from 10K tps to 300 tps depending on file type − Fans go crazy, high power draw wh
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Warren's Abstract Machine: A Tutorial Reconstruction
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How I Built and Published a .NET NuGet Package for the Giant SMS API
A while back, I needed to integrate SMS into a .NET project. Giant SMS had a REST API, but no official .NET client. The only existing library was a PHP one from 6–7 years ago, and it only covered two methods: send and getBalance. So I built my own. It now has nearly 2,000 downloads on NuGet. Here's exactly how I did it. The Problem Wiring up raw HTTP calls to the Giant SMS API in every project gets repetitive fast: Manually setting Authorization headers Remembering which endpoints use token auth vs. username/password Deserializing responses every time Scattering credentials across your codebase I wanted something that felt native to .NET. Configure once in appsettings.json , register with DI, and just call a method. Designing the Public API The first decision was the interface. I wanted consumers to never touch HttpClient directly, and I wanted methods that mapped clearly to what the API actually does: public interface IGiantSmsService { bool IsReady { get ; } Task < SingleSmsResponse > SendSingleMessage ( string to , string msg ); Task < SingleSmsResponse > SendMessageWithToken ( SingleMessageRequest messageRequest ); Task < BaseResponse > SendBulkMessages ( BulkMessageRequest messageRequest ); Task < SingleSmsResponse > CheckMessageStatus ( string messageId ); Task < BaseResponse > GetBalance (); Task < SenderIdResponse > GetSenderIds (); Task < BaseResponse > RegisterSenderId ( RegisterSenderIdRequest senderIdRequest ); } Seven methods, the full surface of the API, no more, no less. The IsReady property is a small but useful addition. It lets consumers do a quick sanity check at startup rather than discovering a missing token on the first SMS send: csharp _isReady = !string.IsNullOrWhiteSpace(_connection.Token) && !string.IsNullOrWhiteSpace(_connection.Username); Handling Two Auth Methods This was the most interesting design challenge. The Giant SMS API uses two different authentication schemes depending on the endpoint: Token-based (Basic Authorization header) —